11/10/2023 0 Comments Rapid rsv antigen test![]() ![]() The sensitivity (percentage of persons with the disease who have a positive test) and specificity (percentage of persons without the disease who have a negative test) of RRADTs for detecting RSV are characteristics of the test. Therefore, among 17 specimens that were RSV-negative by PCR, eight were positive by RRADT, for a false-positivity rate of 47%. All nasopharyngeal specimen PCR results were confirmed at CDC. ![]() A nasopharyngeal swab specimen from one other asymptomatic neonate with a positive RRADT tested positive for human coronavirus 229E by PCR. Sixteen nasopharyngeal specimens were negative for all 18 virus targets three were positive for RSV-A, including the specimens from neonates A and B and from one asymptomatic neonate whose RRADT result was positive. On March 25, the same 20 nasopharyngeal specimens were sent to the Wisconsin State Laboratory of Hygiene for confirmatory testing using a multiplex respiratory virus real-time polymerase chain reaction (PCR) panel (eSensor, GenMark Diagnostics, Inc.) that targets 18 viruses, including RSV subgroups A and B. All 20 RRADTs were performed at the hospital laboratory. Later that day, nasopharyngeal swab specimens from the remaining 16 asymptomatic NICU patients were tested using the same RRADT seven tests were positive, making a total of 11 positives. The following day, because of concern about the possibility of more widespread RSV infection, RRADT was used to test nasopharyngeal swab specimens from neonate B, aged 1 month, who had resided in a different hospital room in the NICU and had developed an increased oxygen requirement, apnea, and poor feeding that day, as well as from two asymptomatic neonates who were hospitalized in the same room with neonate A all three were positive. A nasopharyngeal swab specimen collected from neonate A was tested using a single-manufacturer rapid RSV antigen detection test (RRADT) at the hospital laboratory the result was positive. On March 23, the index patient (neonate A), aged 3 days, had feeding intolerance and apnea. On March 25, 2015, the Wisconsin Division of Public Health was notified of a possible respiratory syncytial virus (RSV) infection outbreak among infants hospitalized in a neonatal intensive care unit (NICU). Elbadawi, MD 1,2 Thomas Haupt, MS 2 Erik Reisdorf, MPH 3 Tonya Danz 3 Jeffrey P. Notes from the Field: Use and Interpretation of a Rapid Respiratory Syncytial Virus Antigen Detection Test Among Infants Hospitalized in a Neonatal Intensive Care Unit - Wisconsin, March 2015 ![]()
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